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UNC5D, also named as KIAA1777 and UNC5H4, belongs to the unc-5 family. It is a receptor for netrin. It may be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ16019; KIAA1777Unc5h4; Netrin receptor UNC5D; netrin receptor Unc5h4; Protein unc-5 homolog 4; Protein unc-5 homolog D; unc-5 homolog 4; unc-5 homolog D; unc5 homolog 4
基因别名: D930029E11Rik; KIAA1777; mKIAA1777; PRO34692; UNC5D; UNC5H4; UNQ6012/PRO34692
UniProt ID: (Human) Q6UXZ4, (Rat) F1LW30, (Mouse) Q8K1S2
Entrez Gene ID: (Human) 137970, (Rat) 306534, (Mouse) 210801