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Invitrogen
UPF2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-66888
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LTRKGNKQQFK ILNVPMSSQL AANHWNQQQA EQEERMRMKK LTLDINERQE QEDYQEMLQS LAQRPAPANT NRERRPRYQH PKGAPNADLI FKTGG
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 92%.
靶标信息
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FRS2/UPF2/LEMD3 fusion; involved in NMD pathway; LEMD3/UPF2 fusion; nonsense mRNA reducing factor 2; smg-3 homolog, nonsense mediated mRNA decay factor; unnamed protein product; up-frameshift suppressor 2 homolog; UPF2 regulator of nonsense transcripts homolog; yeast Upf2p homolog
基因别名: HUPF2; RENT2; smg-3
UniProt ID: (Human) Q9HAU5
Entrez Gene ID: (Human) 26019
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