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USP16 Antibody (PA5-42775) in IHC
Immunofluorescence analysis of human brain stems (NT2) cells using an anti-USP16 polyclonal antibody (Product # PA5-42775). Primary Antibody Dilution: 1:500; Secondary Antibody: Goat anti-rabbit Alexa Fluor 594; Secondary Antibody Dilution: 1:1000.; LANE 2).
Product Details
PA5-42775
产品规格
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human USP16
Conjugate
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2576307
Product Specific Information
Peptide sequence: CKTDNKVKDK AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 79%; Pig: 92%; Rabbit: 86%; Rat: 86%
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 16; Ubiquitin carboxyl-terminal hydrolase 16; ubiquitin specific protease 16; Ubiquitin thioesterase 16; ubiquitin thiolesterase 16; Ubiquitin-processing protease UBP-M; ubiquitin-specific processing protease 16; Ubiquitin-specific-processing protease 16; USP16
Gene Aliases: MSTP039; UBP-M; UBPM; USP16
UniProt ID: (Human) Q9Y5T5
Entrez Gene ID: (Human) 10600
Molecular Function:
cysteine protease
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
cell cycle
mitotic nuclear division
histone deubiquitination
monoubiquitinated histone H2A deubiquitination
positive regulation of transcription, DNA-templated
positive regulation of translational elongation
positive regulation of transcription from RNA polymerase II promoter
protein homotetramerization
cell division
regulation of cell cycle
histone H2A K63-linked deubiquitination
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