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Invitrogen
USP37 Polyclonal Antibody
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产品信息
PA5-60939
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human USP37
偶联物
形式
Liquid
浓度
0.05 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: TGITKWKEGS FEIVEKENKV SLVVHYNTGG IPRIFQLSHN IKNVVLRPSG AKQSRLMLTL QDNSFLSIDK VPSKDAEEMR LFLDAVHQNR LPAAMKPSQG SGSFGAILGS RTSQKETSR
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
靶标信息
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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