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Invitrogen
Urokinase Polyclonal Antibody
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产品信息
PA1-36015
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Purified native HMW-tcuPA and LMW-scuPA (mixture 50/50), isolated from human urine.
偶联物
形式
Lyophilized
保存条件
4°C
运输条件
Wet ice
RRID
产品详细信息
This antibody has been pre-absorbed with immobilized total human serum proteins to remove non-specific antibodies. This antibody is known to bind human HMW-scuPA (54 kDa), HMW-tsuPA (52 kDa), and LMW-scuPA (33 kDa), completely inhibiting the ability of Urokinase to activate plasminogen.
Reconstitute with 1 mL of distilled water and add preservative if preferred.
靶标信息
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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