This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
蛋白别名: Tamm-Horsfall urinary glycoprotein; THP; Uromodulin; Uromodulin, secreted form; uromucoid; uromucoid uromucoid
基因别名: ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; THGP; THP; UMOD
UniProt ID: (Human) P07911
Entrez Gene ID: (Human) 7369
分子生物学功能: transmembrane signal receptor