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GenScript
Ustekinumab Polyclonal Antibody
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Ustekinumab Antibody (A02123-40) in ELISA
ELISA binding of Anti-Ustekinumab Antibody, pAb, Rabbit (GenScript, A02123-40) with Ustekinumab. Coating antigen: Ustekinumab, 1 µg/mL. Anti-Ustekinumab Antibody, pAb, Rabbit (GenScript, A02123-40) dilution start from 1,000 ng/mL. EC50= 9.187 ng/mL.
产品信息
A02123-40
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Ustekinumab
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute the lyophilized powder with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.
The lyophilized product remains stable up to 1 year at -20 °C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below. Avoid repeated freezing and thawing cycles.
靶标信息
Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. 2It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. 2It is a targeted biologic disease-modifying anti-rheumatic pharmaceutical (bDMARDs) that is used in the management of various inflammatory conditions that involve the activation of IL-12 and IL-23 signaling pathways. Interleukin (IL)-12 and IL-23 are heterodimeric cytokines that evoke immune and inflammatory responses, such as natural killer cell activation and CD4+ T-cell differentiation and activation. The role of IL-12 and IL-23 were implicated in a variety of chronic inflammatory conditions, such as psoriasis and inflammatory bowel diseases. They modulate lymphocyte function, including T-helper (Th) 1 and Th17 cell subsets, 2as CD4+ T cells can differentiate into T-helper (Th) effector lineages based on the environment. Th cells can further activate the downstream pro-inflammatory mediators and transcription factors such as TNFalpha and IFNgamma that drive innate and adaptive immunity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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