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Invitrogen
VAMP1/VAMP2 Monoclonal Antibody (SP10)
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产品信息
MA5-17608
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgM
分类
Monoclonal
类型
Antibody
克隆号
SP10
抗原
Human Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2(aa 33-96).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17608 targets VAMP/synaptobrevin in ELISA, FACS, and WB applications and shows reactivity with Human samples.
The MA5-17608 immunogen is human Synaptobrevin 1 (aa 1-118) and Synaptobrevin 2(aa 33-96).
靶标信息
Vesicle-associated membrane protein 2 is essential for cAMP-regulated exocytosis. VAMP (also know as synaptobrevin) is part of the synaptic vesicle docking and fusion complex and plays a central role in neuroexocytosis. Two VAMP (vesicle-associated membrane protein) isoforms are expressed in the nervous system and are differently distributed among the specialized parts of the tissue. VAMP-1 and -2 are present in all tissues tested, including kidney, adrenal gland, liver, pancreas, thyroid, heart, and smooth muscle. The two isoforms are differentially expressed in various tissues and their level may depend on differentiation. VAMP-1 is restricted to exocrine pancreas and to kidney tubular cells, whereas VAMP-2 is the predominant isoform present in Langerhans islets and in glomerular cells. Both isoforms show a patchy vesicular intracellular distribution in confocal microscopy. Evidence for the importance of neuronal VAMPproteins in the physiology of all cells is indicated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: synaptobrevin 2; Synaptobrevin-1; Synaptobrevin-2; VAMP-1; VAMP-2; Vesicle-associated membrane protein 1; vesicle-associated membrane protein 1 (synaptobrevin 1); Vesicle-associated membrane protein 2; vesicle-associated membrane protein 2 (synaptobrevin 2)
基因别名: SPAX1; SYB1; SYB2; VAMP-1; VAMP-2; VAMP1; VAMP2
UniProt ID: (Human) P23763, (Human) P63027
Entrez Gene ID: (Human) 6843, (Human) 6844
exocytosis
vesicle fusion
SNARE complex assembly
protein complex assembly
post-Golgi vesicle-mediated transport
neurotransmitter secretion
response to glucose
glutamate secretion
protein transport
synaptic vesicle exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
cellular response to insulin stimulus
Golgi to plasma membrane protein transport
eosinophil degranulation
neutrophil degranulation
natural killer cell degranulation
long-term synaptic potentiation
regulation of vesicle-mediated transport
membrane fusion
mucus secretion
positive regulation of intracellular protein transport
regulation of delayed rectifier potassium channel activity
regulation of histamine secretion by mast cell
