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Invitrogen
VAV1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 3
VAV1 Antibody (PA5-17834) in WB
Western blot was performed using Anti-VAV1 Polyclonal Antibody (Product # PA5-17834) and a 98kDa band corresponding to VAV1 was observed in Raji, MOLT-4, Jurkat, THP-1, Mouse Thymus but not in T-47D, MCF7 and Mouse Kidney. Whole cell extracts (30ug) of Raji (Lane 1), MOLT-4 (Lane 2), Jurkat (Lane 3), THP-1 (Lane 4), T-47D (Lane 5) and MCF7 (Lane 6), and Tissue extracts (30ug) of Mouse Thymus (Lane 7) and Mouse Kidney (Lane 8) were electrophoresed using NuPAGE® 10 % Bis-Tris gel (Product # NP0302BOX). Resolved proteins were then transferred... View More
Product Details
PA5-17834
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Tyr174 of human Vav
Conjugate
Unconjugated
形式
Liquid
浓度
27 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
RRID
AB_10987031
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with Vav2, Vav3 or CelVav.
Target Information
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: oncogene vav; p95; p95vav; Proto-oncogene vav; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav oncogene; vav proto-oncogene
Gene Aliases: VAV; vav-T; VAV1
UniProt ID: (Human) P15498, (Mouse) Q8BTV7
Entrez Gene ID: (Human) 7409, (Rat) 25156, (Mouse) 22324
immune response-regulating cell surface receptor signaling pathway
phagocytosis
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
T cell differentiation
neutrophil chemotaxis
intracellular signal transduction
T cell activation
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
cell development
reactive oxygen species metabolic process
regulation of transcription, DNA-templated
regulation of cell size
regulation of phosphatidylinositol 3-kinase signaling
platelet activation
T cell costimulation
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of apoptotic process
phosphatidylinositol phosphorylation
vascular endothelial growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
regulation of small GTPase mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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