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Positive control: MCF7 cell lysate, HEK-293 cell lysate, Jurkat cell lysate, Mouse brain tissue lysate, Mouse heart tissue lysate, Rat brain tissue lysate, Rat heart tissue lysate.
Subcellular location: Mitochondrion outer membrane, Membrane.
VDAC1, VDAC2, and VDAC3 genes encode for voltage-dependent anion channels (VDACs) which are integral membrane proteins located in the outer mitochondrial membrane. VDAC1 is the most prominent of the three and is involved in the regulation of metabolic and energetic cross-talk between mitochondria and the rest of the cell. VDAC2 and VDAC3 share structural similarities with VDAC1 but differ in their expression patterns and regulatory functions. VDAC channels are crucial for the transport of ions and metabolites, including ATP and ADP, across the mitochondrial membrane and thus play a central role in cellular energy metabolism and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: B36-VDAC; channel protein VDAC3; mitochondrial outer membrane protein; mitochondrial voltage dependent anion channel 3; mVDAC1; mVDAC3; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Outer mitochondrial membrane protein porin 2; Outer mitochondrial membrane protein porin 3; Plasmalemmal porin; Porin 31HL; Porin 31HM; rVDAC1; rVDAC3; VDAC-1; VDAC-2; VDAC-3; VDAC-5; VDAC-6; voltage-dependent anion channel 2; voltage-dependent anion channel 3; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 2; Voltage-dependent anion-selective channel protein 3; Voltage-dependent anion-selective channel protein 5; Voltage-dependent anion-selective channel protein 6
基因别名: AL033343; HD-VDAC3; mVDAC2; mVDAC6; POR; PORIN; VDAC; VDAC-1; VDAC-3; VDAC1; VDAC2; VDAC3; Vdac5; Vdac6
UniProt ID: (Human) P21796, (Human) P45880, (Human) Q9Y277, (Mouse) Q60932, (Rat) Q9Z2L0, (Mouse) Q60930, (Rat) P81155, (Mouse) Q60931, (Rat) Q9R1Z0
Entrez Gene ID: (Human) 7416, (Human) 7417, (Human) 7419, (Mouse) 22333, (Rat) 83529, (Mouse) 22334, (Rat) 83531, (Mouse) 22335, (Rat) 83532