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Invitrogen
VE-cadherin Polyclonal Antibody
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VE-cadherin Antibody (PA1-84328)
Down-regulation of VE-cadherin contributed to the sensitivity of PMVECs to apoptosis induced by AngII. A. Knockdown of VE-cadherin by RNAi was validated using Western blot analysis. B, C. Cell apoptosis determined by flow cytometry. *P < 0.05 versus control group; #P < 0.05 versus AngII group. {KD}
产品信息
PA1-84328
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragments corresponding to amio acids 1-258 of VE-cadherin.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
This antibody does not cross react with N-cadherin, which is also expressed by endothelial cells. It has also been reported to block adhesive properties of VE-cadherin.
For FACS analysis, use 10ul of the suggested working dilution to label 1x10^6 cells in 100ul.
靶标信息
VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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