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Invitrogen
VEGF Receptor 2 Recombinant Rabbit Monoclonal Antibody (RM515)
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产品信息
MA562151
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM515
抗原
A peptide corresponding to residues near the C-terminus of human VEGFR2.
偶联物
形式
Liquid
浓度
Conc. Not Determined
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
This antibody reacts to human VEGFR2 (KDR) (FLK-1) (CD309).
靶标信息
KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; VEGF R2; VEGFR-2
基因别名: CD309; FLK1; KDR; VEGFR; VEGFR2
UniProt ID: (Human) P35968
Entrez Gene ID: (Human) 3791
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
growth factor binding
Hsp90 protein binding
transmembrane signal receptor
angiogenesis
vasculogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
endothelium development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
positive regulation of macroautophagy
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
extracellular matrix organization
positive regulation of cell migration
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
peptidyl-tyrosine autophosphorylation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
positive regulation of mitochondrial depolarization
positive regulation of ERK1 and ERK2 cascade
positive regulation of mitochondrial fission
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis
