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Human VNN1 shares 82.2% amino acid (aa) sequence identity with mouse VNN1.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.
蛋白别名: Pantetheinase; Pantetheine hydrolase; Tiff66; Vanin-1; Vanin1; vannin 1; Vascular non-inflammatory molecule 1
基因别名: HDLCQ8; Tiff66; VNN1
UniProt ID: (Human) O95497
Entrez Gene ID: (Human) 8876