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Proteintech
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Immunogen sequence: MSPSYHQSK GDPTAKKGTS EPVLDPQQIQ AFDQLCRLYR GSSRLALLTE LSQNRSSESY RPFSGSQSAP AFNSIFQNEN FQLQLIPPPV TED (56-147 aa encoded by BC001001)
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: vacuolar protein sorting 8 homolog; vacuolar protein sorting 8 homolog (S. cerevisiae); Vacuolar protein sorting-associated protein 8 homolog; VPS8 CORVET complex subunit
基因别名: AI315068; AU040738; KIAA0804; mKIAA0804; RGD1309443; VPS8
UniProt ID: (Human) Q8N3P4, (Mouse) Q0P5W1
Entrez Gene ID: (Human) 23355, (Rat) 287990, (Mouse) 209018