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Invitrogen
Vimentin Polyclonal Antibody, HRP
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产品信息
PA1-74172
产品规格
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant vimentin NH2 terminal 20 kDa fragment.
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-74172 detects Vimentin from human samples.
PA1-74172 has been successfully used in ELISA and immunoelectrophoresis applications.
The PA1-74172 immunogen is recombinant vimentin NH2 terminal 20 kDa fragment.
靶标信息
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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