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Invitrogen
Viral MIP-I Monoclonal Antibody (84420)
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产品信息
MA5-61893
产品规格
种属反应
Virus
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
84420
抗原
E. coli-derived recombinant human herpes virus-8 MIP-I, Ala25-Ala95
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
MIP-1, also known as Macrophage Inflammatory Protein-1, is a chemokine encoded by the CCL3 gene. This protein is a member of the CC chemokine family and plays a critical role in the immune response by recruiting and activating various types of leukocytes, including macrophages, T cells, and dendritic cells, to sites of infection or injury. MIP-1 is involved in the inflammatory response, promoting the release of other cytokines and chemokines that amplify the immune reaction. It binds to specific receptors on the surface of target cells, such as CCR1 and CCR5, to exert its effects. Elevated levels of MIP-1 have been associated with various inflammatory and autoimmune conditions, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. Additionally, MIP-1 is implicated in the pathogenesis of certain cancers and HIV infection, where it can influence tumor progression and viral replication. Understanding the regulation and function of MIP-1 is crucial for developing targeted therapies aimed at modulating immune responses and treating diseases characterized by excessive inflammation or immune dysregulation. Research into MIP-1 also provides insights into the broader mechanisms of chemokine-mediated cell signaling and its potential therapeutic applications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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