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Positive Control: MCF-7, U87-MG
Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (87%), Xenopus laevis (90%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
WDR24, as a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. WDR24 is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GATOR2 complex protein WDR24; WD repeat-containing protein 24
基因别名: C16orf21; JFP7; WDR24
UniProt ID: (Human) Q96S15
Entrez Gene ID: (Human) 84219