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Immunogen sequence: KQQLAAEPVP TGFFNMWGFG RVSKQASQPV KKQQENATSC SLELIGDLIG HSSSVEMFLY FEDHGLVTCS ADHLIILWKN GERESGLR
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: WD repeat-containing protein 41
基因别名: MSTP048; WDR41
UniProt ID: (Human) Q9NV62
Entrez Gene ID: (Human) 55255