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Proteintech
WDR59 Polyclonal Antibody
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产品信息
26289-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
WDR59 fusion protein Ag23495
偶联物
形式
Liquid
浓度
750 µg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: WKSKREGSDS GNRQIKAAGK VIIQDIACLL PVHKSLGELY ILNVNDIQET CQKNAASALL VGRKDLVQVW SLATVATDLC LGPKSDPDLE TPWARHPFGR QLLESLLAHY CRLRDVQTLA MLCSVFEAQS RPQGLPNPFG PFPNRSSNLV VSHSRYPSFT SSGSCSSMSD PGLNTGGWNI AGREAEHLSS PWGESSPEEL RFGSLTYSDP RERERDQHDK NKRLLDPANT QQFDDFKKCY GEILYRWGLR EKRAEVLKFV SCPPDPHKGI EFGVYCSHCR SEVRGTQCAI CKGFTFQCAI CHVAVRGSSN FCLTCGHGGH TSHMMEWFRT QEVCPTGCGC HCLLESTF
靶标信息
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CUL4- and DDB1-associated WDR protein 12; GATOR2 complex protein WDR59; WD repeat-containing protein 59
基因别名: 5430401O09Rik; Cdw12; FP977; KIAA1923; WDR59
UniProt ID: (Human) Q9HA43, (Mouse) Q8C0M0
Entrez Gene ID: (Human) 79726, (Mouse) 319481
