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Invitrogen
WFS1 Polyclonal Antibody
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产品信息
PA5-56064
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KHPCHIKKFD RYKFEITVGM PFSSGADGSR SREEDDVTKD IVLRASSEFK SVLLSLRQGS LIEFSTILEG RLGSKWPVFE LKAISCLNCM AQLSPTRRHV KIEHDW
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
靶标信息
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolframin
基因别名: CTRCT41; WFRS; WFS; WFS1; WFSL
UniProt ID: (Human) O76024
Entrez Gene ID: (Human) 7466
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
ER overload response
visual perception
sensory perception of sound
protein maturation by protein folding
ER-associated ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
endoplasmic reticulum calcium ion homeostasis
response to endoplasmic reticulum stress
IRE1-mediated unfolded protein response
glucose homeostasis
negative regulation of programmed cell death
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron apoptotic process
positive regulation of adenylate cyclase activity
positive regulation of growth
protein stabilization
neurological system process
positive regulation of protein metabolic process
positive regulation of calcium ion transport
calcium ion homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of ATF6-mediated unfolded protein response
negative regulation of type B pancreatic cell apoptotic process
