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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:2,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:50 - 1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant fusion protein containing a sequence corresponding to amino acids 187-436 of human WIPI2. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
3.97 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.3, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2808516 |
Immunogen sequence: LAALAFDASG TKLATASEKG TVIRVFSIPE GQKLFEFRRG VKRCVSICSL AFSMDGMFLS ASSNTETVHI FKLETVKEKP PEEPTTWTGY FGKVLMASTS YLPSQVTEMF NQGRAFATVR LPFCGHKNIC SLATIQKIPR LLVGAADGYL YMYNLDPQEG GECALMKQHR LDGSLETTNE ILDSASHDCP LVTQTYGAAA GKGTYVPSSP TRLAYTDDLG AVGGACLEDE ASALRLDEDS EHPPMILRTD; Positive Samples: Jurkat, BT-474; Cellular Location: Cytoplasmic side, Peripheral membrane protein, Preautophagosomal structure membrane
WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI49-like protein 2
基因别名: 1110018O08Rik; 2510001I10Rik; ATG18B; Atg21; CGI-50; WIPI-2; WIPI2
UniProt ID: (Human) Q9Y4P8, (Mouse) Q80W47
Entrez Gene ID: (Human) 26100, (Mouse) 74781
