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Invitrogen
WIPI2 Polyclonal Antibody
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WIPI2 Antibody (PA5-96714) in WB
Western blot analysis of WIPI2 in extracts of various cell lines. Samples were incubated with WIPI2 Polyclonal antibody (Product # PA5-96714) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-96714
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 187-436 of human WIPI2 (NP_0570872)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.95 mg/mL
规格
95 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LAALAFDASG TKLATASEKG TVIRVFSIPE GQKLFEFRRG VKRCVSICSL AFSMDGMFLS ASSNTETVHI FKLETVKEKP PEEPTTWTGY FGKVLMASTS YLPSQVTEMF NQGRAFATVR LPFCGHKNIC SLATIQKIPR LLVGAADGYL YMYNLDPQEG GECALMKQHR LDGSLETTNE ILDSASHDCP LVTQTYGAAA GKGTYVPSSP TRLAYTDDLG AVGGACLEDE ASALRLDEDS EHPPMILRTD; Positive Samples: Jurkat, BT-474; Cellular Location: Cytoplasmic side, Peripheral membrane protein, Preautophagosomal structure membrane
靶标信息
WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: WD repeat domain phosphoinositide-interacting protein 2; WIPI-2
基因别名: 1110018O08Rik; 2510001I10Rik; Wipi2
UniProt ID: (Mouse) Q80W47, (Rat) Q6AY57
Entrez Gene ID: (Mouse) 74781, (Rat) 288498
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