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Abnova
WISP3 Polyclonal Antibody, MaxPab™
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产品信息
H00008838-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
WISP3 (NP_937882.1, 1 a.a. approximately 372 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MNKRRLLYPS GWLHGPSDMQ GLLFSTLLLA GLAQFCCRVQ GTGPLDTTPE GRPGEVSDAP QRKQFCHWPC KCPQQKPRCP PGVSLVRDGC GCCKICAKQP GEICNEADLC DPHKGLYCDY SVDRPRYETG VCAYLVAVGC EFNQVHYHNG QVFQPNPLFS CLCVSGAIGC TPLFIPKLAG SHCSGAKGGK KSDQSNCSLE PLLQQLSTSY KTMPAYRNLP LIWKKKCLVQ ATKWTPCSRT CGMGISNRVT NENSNCEMRK EKRLCYIQPC DSNILKTIKI PKGKTCQPTF QLSKAEKFVF SGCSSTQSYK PTFCGICLDK RCCIPNKSKM ITIQFDCPNE GSFKWKMLWI TSCVCQRNCR EPGDIFSELK IL
靶标信息
WISP3 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. WISP3 is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of the WISP3 gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CCN family member 6; Cellular communication network factor 6; WISP-3; WNT1-inducible-signaling pathway protein 3
基因别名: CCN6; LIBC; PPAC; PPD; UNQ462/PRO790/PRO956; WISP-3; WISP3
UniProt ID: (Human) O95389
Entrez Gene ID: (Human) 8838
