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WNT16 Antibody (710893) in IHC (P)
Immunohistochemistry analysis of Wnt 16 showing staining in the cytoplasm of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, w... View More
产品信息
710893
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
17HCLC
抗原
Peptides corresponding to Human WNT16 (aa 61:72, 261:276, 241:254)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2576756
产品详细信息
This antibody is predicted to react with Monkey, Cat, Bovine and Pig.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. WNT15 is also a ligand for members of the frizzled family of seven transmembrane receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Protein Wnt-16; wingless-type MMTV integration site family member 16; wingless-type MMTV integration site family member 16b; wingless-type MMTV integration site family, member 16
基因别名: WNT16
UniProt ID: (Human) Q9UBV4
Entrez Gene ID: (Human) 51384
optic cup formation involved in camera-type eye development
positive regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
Wnt signaling pathway
neuron differentiation
keratinocyte differentiation
keratinocyte proliferation
cell fate commitment
positive regulation of JNK cascade
bone remodeling
cardiac epithelial to mesenchymal transition
negative regulation of cell death
replicative senescence
oxidative stress-induced premature senescence
