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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
酶联免疫吸附实验 (ELISA) |
Assay-Dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Mouse / IgG2a, kappa |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
3E10 |
抗原 |
WSB1 (AAH21110.1, 53 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Affinity chromatography |
保存液 |
PBS, pH 7.4 |
内含物 |
no preservative |
保存条件 |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2576270 |
Peptide Sequence: QGHRTVKLVP WSQCLQNFLL HGTKNVTNSS SLRLPRQNSD GGQKNKPREH IIDCGDIVWS LAFGSSVPEK QSRCVNIEWH RFRFG
WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: SOCS box-containing WD protein SWiP-1; WD repeat and SOCS box-containing 1; WD repeat and SOCS box-containing protein 1; WSB-1
基因别名: SWIP1; WSB-1; WSB1
UniProt ID: (Human) Q9Y6I7
Entrez Gene ID: (Human) 26118
