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Peptide Sequence: QGHRTVKLVP WSQCLQNFLL HGTKNVTNSS SLRLPRQNSD GGQKNKPREH IIDCGDIVWS LAFGSSVPEK QSRCVNIEWH RFRFG
WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Protein Aliases: SOCS box-containing WD protein SWiP-1; WD repeat and SOCS box-containing 1; WD repeat and SOCS box-containing protein 1; WSB-1
Gene Aliases: SWIP1; WSB-1; WSB1
UniProt ID: (Human) Q9Y6I7
Entrez Gene ID: (Human) 26118
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