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Fabgennix
WWOX3 Polyclonal Antibody
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产品信息
WWOX3-301AP
产品规格
种属反应
Human,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 250-300 on human WWOXdelta5-8 protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1; short chain dehydrogenase/reductase family 41C, member 1; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX
基因别名: D16S432E; EIEE28; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1; WWOX
UniProt ID: (Human) Q9NZC7
Entrez Gene ID: (Human) 51741, (Rat) 292041
osteoblast differentiation
steroid metabolic process
Wnt signaling pathway
negative regulation of Wnt signaling pathway
positive regulation of transcription from RNA polymerase II promoter
skeletal system morphogenesis
oxidation-reduction process
cellular response to transforming growth factor beta stimulus
intrinsic apoptotic signaling pathway by p53 class mediator
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
biological_process
