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Proteintech
WWTR1 Monoclonal Antibody (2A12A10), CoraLite® Plus 488
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产品信息
CL488-66500
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
2A12A10
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ QQQKLRLQRI QMERERIRMR QEELMRQEAA LCRQLPMEAE TLAPVQAAVN PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF LSNVDEMDTG ENAGQTPMNI NPQQTRFPDF LDCLPGTNVD LGTLESEDLI PLFNDVESAL NKSEPFLTWL
靶标信息
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; transcriptional co-activator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); transcriptional coactivator with PDZ binding motif; Transcriptional coactivator with PDZ-binding motif; WW domain-containing transcription regulator protein 1
基因别名: 2310058J06Rik; 2610021I22Rik; C78399; TAZ; WWTR1
UniProt ID: (Human) Q9GZV5, (Mouse) Q9EPK5
Entrez Gene ID: (Human) 25937, (Mouse) 97064, (Rat) 295062
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
negative regulation of protein phosphorylation
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
negative regulation of protein kinase activity
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
protein ubiquitination
stem cell division
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
glomerulus development
multicellular organism growth
hippo signaling
negative regulation of catenin import into nucleus
negative regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
mesenchymal cell differentiation
cilium morphogenesis
regulation of SMAD protein import into nucleus
kidney morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
negative regulation of canonical Wnt signaling pathway
transcription, DNA-templated
regulation of canonical Wnt signaling pathway
regulation of nucleic acid-templated transcription
