FIGURE: 1 / 1
Immunogen sequence: ILTALQLHQQ KERFPTQHQR LSLGCPVLDA LLRGGLPLDG ITELAGRSSA GKTQLALQLC LAVQFPRQHG GLEAGAVYIC TEDAFPHKRL QQLMAQQPRL RTDVPGELLQ KLRFGSQIFI EHVADVDTLL ECVNKKVPVL LSRGMARLVV IDSVAAPFRC EFDSQASAPR ARHLQSLGAT LRELSSAFQS PVLCINQVTE AMEEQGAAHG PLGFWDERVS PALGITWANQ LLVRLLADRL REEEAALGCP ARTLRVLSAP HLPPSSCSYT ISAEGVRGTP GTQSH; Positive Samples: HL-60; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, perinuclear region
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
Protein Aliases: DNA repair protein XRCC3; RAD51 like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3; XRCC 3
Gene Aliases: CMM6; XRCC3
UniProt ID: (Human) O43542
Entrez Gene ID: (Human) 7517