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Immunogen sequence: ILTALQLHQQ KERFPTQHQR LSLGCPVLDA LLRGGLPLDG ITELAGRSSA GKTQLALQLC LAVQFPRQHG GLEAGAVYIC TEDAFPHKRL QQLMAQQPRL RTDVPGELLQ KLRFGSQIFI EHVADVDTLL ECVNKKVPVL LSRGMARLVV IDSVAAPFRC EFDSQASAPR ARHLQSLGAT LRELSSAFQS PVLCINQVTE AMEEQGAAHG PLGFWDERVS PALGITWANQ LLVRLLADRL REEEAALGCP ARTLRVLSAP HLPPSSCSYT ISAEGVRGTP GTQSH; Positive Samples: HL-60; Cellular Location: Cytoplasm, Mitochondrion, Nucleus, perinuclear region
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DNA repair protein XRCC3; DNA repair protein XRCC3-like; RAD51 like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross-complementing protein 3; XRCC 3
基因别名: 4432412E01Rik; AI182522; AW537713; CMM6; XRCC3
UniProt ID: (Human) O43542, (Mouse) Q9CXE6
Entrez Gene ID: (Rat) 102551085, (Human) 7517, (Mouse) 74335
分子生物学功能:
DNA metabolism protein
nucleic acid metabolism protein
