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Proteintech
YAP1 Polyclonal Antibody
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产品信息
13584-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Chicken,
Human,
Mouse,
Rat,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
YAP1 Fusion Protein Ag4510 (155-504 aa encoded by BC038235)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody. The calculated molecular weight of YAP1 is 54 kDa, but phosphorylated YAP1 is about 65 kDa.
Immunogen sequence: PTAQHLRQS SFEIPDDVPL PAGWEMAKTS SGQRYFLNHI DQTTTWQDPR KAMLSQMNVT APTSPPVQQN MMNSASGPLP DGWEQAMTQD GEIYYINHKN KTTSWLDPRL DPRFAMNQRI SQSAPVKQPP PLAPQSPQGG VMGGSNSNQQ QQMRLQQLQM EKERLRLKQQ ELLRQAMRNI NPSTANSPKC QELALRSQLP TLEQDGGTQN PVSSPGMSQE LRTMTTNSSD PFLNSGTYHS RDESTDSGLS MSSYSVPRTP DDFLNSVDEM DTGDTINQST LPSQQNRFPD YLEAIPGTNV DLGTLEGDGM NIEGEELMPS LQEALSSDIL NDMESVLAAT KLDKESFLTW L (155-504 aa encoded by BC038235)
靶标信息
YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 65 kDa Yes-associated protein; Protein yorkie homolog; Transcriptional coactivator YAP1; Yes-associated protein 1; yes-associated protein 2; Yes-associated protein YAP65 homolog; yorkie homolog
基因别名: COB1; YAP; YAP1; YAP2; YAP65; YKI
UniProt ID: (Human) P46937
Entrez Gene ID: (Human) 10413
RNA polymerase II core promoter sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
chromatin binding
transcription coactivator activity
transcription corepressor activity
protein binding
protein C-terminus binding
transcription regulatory region DNA binding
proline-rich region binding
transcription cofactor
cell morphogenesis
vasculogenesis
embryonic heart tube morphogenesis
transcription initiation from RNA polymerase II promoter
cellular response to DNA damage stimulus
cell proliferation
positive regulation of cell proliferation
regulation of keratinocyte proliferation
keratinocyte differentiation
negative regulation of epithelial cell differentiation
notochord development
somatic stem cell population maintenance
hippo signaling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of organ growth
paraxial mesoderm development
lateral mesoderm development
regulation of neurogenesis
contact inhibition
bud elongation involved in lung branching
lung epithelial cell differentiation
cellular response to retinoic acid
cellular response to gamma radiation
regulation of stem cell proliferation
regulation of metanephric nephron tubule epithelial cell differentiation
positive regulation of canonical Wnt signaling pathway
positive regulation of stem cell population maintenance
negative regulation of nucleic acid-templated transcription
negative regulation of stem cell differentiation
negative regulation of extrinsic apoptotic signaling pathway
