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Invitrogen
Yellow Fever Virus NS5 (strain 17D vaccine) Recombinant Rabbit Monoclonal Antibody (HL2916)
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Yellow Fever Virus NS5 (strain 17D vaccine) Antibody (MA5-56927) in WB
Western Blot analysis of Yellow Fever Virus NS5 (strain 17D vaccine) using Yellow Fever Virus NS5 (strain 17D vaccine) Recombinant Monoclonal Antibody (Product # MA5-56927). Non-transfected (–) and transfected (+) 293T whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with Yellow Fever Virus NS5 (strain 17D vaccine) antibody diluted at 1:5,000 A HRP-conjugated anti-rab... View More
产品信息
MA5-56927
产品规格
种属反应
Virus
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2916
抗原
Recombinant fragment of Yellow Fever virus NS5 protein. (strain 17D vaccine)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
The NS5 protein of the Yellow Fever Virus (YFV) is the largest and most functionally diverse non-structural protein, playing a pivotal role in viral replication and transcription. This multifunctional protein possesses both RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) activities, which are essential for the synthesis and capping of viral RNA. The RdRp activity of NS5 is responsible for copying the viral RNA genome, while the MTase activity adds a cap to the viral RNA, which is crucial for RNA stability and translation. Additionally, NS5 interacts with various host cell factors to modulate immune responses, aiding in viral evasion and persistence. Due to its critical functions in the viral life cycle, NS5 is a prime target for antiviral drug development. Inhibiting NS5 can potentially disrupt viral replication and reduce viral load, making it a key focus for therapeutic intervention. Ongoing research aims to elucidate the detailed mechanisms of NS5's activities and interactions, which could lead to the development of effective antiviral agents against yellow fever and other flavivirus-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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