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Proteintech
ZBED1 Polyclonal Antibody
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产品信息
26140-1-AP
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZBED1 Fusion Protein Ag23578 (343-694 aa encoded by BC015030)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: HCMLVSNRV SWWGSTLAML QRLKEQQFVI AGVLVEDSNN HHLMLEASEW ATIEGLVELL QPFKQVAEML SASRYPTISM VKPLLHMLLN TTLNIKETDS KELSMAKEVI AKELSKTYQE TPEIDMFLNV ATFLDPRYKR LPFLSAFERQ QVENRVVEEA KGLLDKVKDG GYRPAEDKIF PVPEEPPVKK LMRTSTPPPA SVINNMLAEI FCQTGGVEDQ EEWHAQVVEE LSNFKSQKVL GLNEDPLKWW SDRLALFPLL PKVLQKYWCV TATRVAPERL FGSAANVVSA KRNRLAPAHV DEQVFLYENA RSGAEAEPED QDEGEWGLDQ EQVFSLGDGV SGGFFGIRDS SFL (343-694 aa encoded by BC015030)
靶标信息
ZBED1, also known as DREF, is the human homolog of the Drosophila protein DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation. RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in the inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting that ZBED1 also plays a role in cell proliferation in human cells. At least 22 ribosomal proteins (RPs) possess ZBED1 binding sites in their promoters; anti-ZBED1 RNAi also resulted in decreased RP gene expression. Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, and this self-association is required for nuclear localization and DNA binding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ac-like transposable element; BED-type zinc finger domain-containing protein 1; DNA replication-related element binding factor; DNA replication-related element-binding factor; dREF homolog; E3 SUMO-protein ligase ZBED1; Putative Ac-like transposable element; Zinc finger BED domain-containing protein 1; zinc finger, BED-type containing 1
基因别名: ALTE; DREF; hDREF; KIAA0785; TRAMP; ZBED1
UniProt ID: (Human) O96006
Entrez Gene ID: (Human) 9189
