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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Despite its predicted molecular weight, ZBED3 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is A-20 cell lysate.
PA5-20767 can be used with blocking peptide PEP-0881.
Axin is a key modulator of the Wnt/beta-catenin pathway and acts as a scaffold protein in phosphorylating and degrading cytoplasmic beta-catenin. ZBED3, a member of the Zinc finger BED-type domain containing superfamily, has been recently identified as an Axin-interacting protein and has been suggested to modulate the Wnt/beta-catenin signaling pathway. RNA interference (RNAi) experiments targeting ZBED3 RNA attenuated Wnt-induced beta-catenin accumulation, lymphoid enhancer binding factor-1-dependent luciferase reporter activity, and Wnt gene expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Axin-interacting protein; Zinc finger BED domain-containing protein 3; zinc finger, BED domain containing 3
基因别名: 0610037K01Rik; 2610005H11Rik; AU018975; AU024588; Zbed3
UniProt ID: (Mouse) Q9D0L1
Entrez Gene ID: (Rat) 361881, (Mouse) 72114