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Invitrogen
ZBTB1 Polyclonal Antibody
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产品信息
PA5-62203
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: CDSCGFGFSC EKLLDEHVLT CTNRHLYQNT RSYHRIVDIR DGKDSNIKAE FGEKDSSKTF SAQTDKYRGD TSQAADDSAS TTGSRK
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 79%.
靶标信息
ZBTB1 acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Zinc finger and BTB domain-containing protein 1
基因别名: KIAA0997; ZBTB1; ZNF909
UniProt ID: (Human) Q9Y2K1
Entrez Gene ID: (Human) 22890
negative regulation of transcription from RNA polymerase II promoter
positive regulation of T cell mediated immunity
DNA repair
chromatin remodeling
cellular response to DNA damage stimulus
translesion synthesis
B cell differentiation
positive regulation of natural killer cell differentiation
T cell differentiation in thymus
cellular response to UV
mRNA transcription from RNA polymerase II promoter
innate immune response
positive regulation of T cell differentiation
thymus development
protein homooligomerization
positive regulation of pro-T cell differentiation
