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Proteintech
ZEB1 Polyclonal Antibody
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产品信息
21544-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZEB1 Fusion Protein Ag16204 (391-740 aa encoded by BC112392)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The calculated molecular weight of ZEB1 is 124 kDa, but the post phosphorylation of protein is about 190-210 kDa. This is a rabbit polyclonal antibody raised against part of the full length of ZEB1 of human.
Immunogen sequence: MVQAVVLPT VGLVSPISIN LSDIQNVLKV AVDGNVIRQV LENNQANLAS KEQETINASP IQQGGHSVIS AISLPLVDQD GTTKIIINYS LEQPSQLQVV PQNLKKENPV ATNSCKSEKL PEDLTVKSEK DKSFEGGVND STCLLCDDCP GDINALPELK HYDLKQPTQP PPLPAAEAEK PESSVSSATG DGNLSPSQPP LKNLLSLLKA YYALNAQPSA EELSKIADSV NLPLDVVKKW FEKMQAGQIS VQSSEPSSPE PGKVNIPAKN NDQPQSANAN EPQDSTVNLQ SPLKMTNSPV LPVGSTTNGS RSSTPSPSPL NLSSSRNTQG YLYTAEGAQE EPQVEPLDLS L (391-740 aa encoded by BC112392)
靶标信息
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Delta EF1; delta-crystallin enhancer binding factor 1; DELTA-EF1; MEB1; MGC133261; Negative regulator of IL2; NIL-2-A; NIL-2-A zinc finger protein; NIL-2A; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; RP11-472N13.4; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); twirler; Zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; zinc finger homeodomain enhancer-binding protein
基因别名: 3110032K11Rik; [delta]EF1; AREB6; BZP; DELTAEF1; FECD6; MEB1; Nil2; NIL2A; PPCD3; TCF-8; Tcf18; TCF8; Tw; ZEB; ZEB1; ZFHEP; ZFHX1A; Zfx1a; Zfx1ha
UniProt ID: (Human) P37275, (Mouse) Q64318
Entrez Gene ID: (Human) 6935, (Mouse) 21417
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
transcription factor binding
zinc ion binding
E-box binding
nucleic acid binding
DNA binding
double-stranded DNA binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
immune response
pattern specification process
central nervous system development
cell proliferation
negative regulation of cell proliferation
regulation of mesenchymal cell proliferation
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell differentiation
regulation of T cell differentiation in thymus
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
embryonic skeletal system morphogenesis
semicircular canal morphogenesis
regulation of smooth muscle cell differentiation
cartilage development
cellular response to amino acid stimulus
cochlea morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
nervous system development
cell differentiation
animal organ development
embryonic morphogenesis
