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Invitrogen
ZNF692 Polyclonal Antibody
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产品信息
PA5-66533
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human ZN692. Recombinant protein control fragment (Product #RP-105243).
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ASTGSQAQSAP TPAWDEDTAQ IGPKRIRKAA KRELMPCDFP GCGRIFSNRQ YLNHHKKYQH IHQKSFSCP
Highest antigen sequence identity to the following orthologs - mouse 90%, rat 89%.
靶标信息
ZNF692, a zinc finger protein, is involved in several cellular processes including nucleolar organization and ribosome biogenesis. It interacts with nucleophosmin (NPM1), regulating nucleolar morphology by modifying NPM1's self-assembly properties and influencing protein synthesis. Knockdown of ZNF692 causes nucleolar redistribution of NPM1 and results in a decreased rate of protein synthesis. Additionally, ZNF692 plays a role in 40S ribosomal subunit maturation by forming a hub with the exosome complex and ribosome biogenesis factors. This gene is upregulated in certain cancers such as clear cell renal cell carcinoma (ccRCC), where its expression is associated with increased cell proliferation, migration, and poor overall survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AICAR responsive element binding protein; Zinc finger protein 692
基因别名: AREBP; ZFP692; ZNF692
UniProt ID: (Human) Q9BU19
Entrez Gene ID: (Human) 55657
