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Proteintech
ZNF746 Polyclonal Antibody
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产品信息
24543-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ZNF746 Fusion Protein Ag21566 (186-531 aa encoded by BC068505)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The calculated molecular weight of ZNF746 is 69 kDa, but phosphorylated ZNF746 is about 80-85 kDa.
Immunogen sequence: MQIKQEGEL QLQEQQALGV EAWAAGQPDI GEEPWGLSQL DSGAGDISTD ATSGVHSNFS TTIPPTSWQT DLPPHHPSSA CSDGTLKLNT AASTEDVKIV IKTEVQEEEV VATPVHPTDL EAHGTLFGPG QATRFFPSPA QEGAWESQGS SFPSQDPVLG LREPARPERD MGELSPAVAQ EETPPGDWLF GGVRWGWNFR CKPPVGLNPR TGPEGLPYSS PDNGEAILDP SQAPRPFNEP CKYPGRTKGF GHKPGLKKHP AAPPGGRPFT CATCGKSFQL QVSLSAHQRS CGAPDGSGPG TGGGGSGSGG GGGGSGGGSA RDGSALRCGE CGRCFTRPAH LIRHRML (186-531 aa encoded by BC068505 )
靶标信息
ZNF746 is a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and represses transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: PARIS; parkin interacting substrate; Parkin-interacting substrate; parkin-interacting sustrate; Zinc finger protein 746
基因别名: 2810407L07Rik; AI317225; PARIS; RGD1306209; Zfp746; ZNF746
UniProt ID: (Human) Q6NUN9, (Mouse) Q3U133
Entrez Gene ID: (Human) 155061, (Mouse) 69228, (Rat) 312303
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
ubiquitin protein ligase binding
transcription regulatory region DNA binding
metal ion binding
nucleic acid binding
DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of neuron death
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
