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Proteintech
ZO-1 Monoclonal Antibody (1G4A1)
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产品信息
66452-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human
已发表种属
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1G4A1
抗原
ZO-1 Fusion Protein Ag16454 (1446-1748 aa encoded by BC111712)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SLHIHSKGA HGEGNSVSLD FQNSLVSKPD PPPSQNKPAT FRPPNREDTA QAAFYPQKSF PDKAPVNGTE QTQKTVTPAY NRFTPKPYTS SARPFERKFE SPKFNHNLLP SETAHKPDLS SKTPTSPKTL VKSHSLAQPP EFDSGVETFS IHAEKPKYQI NNISTVPKAI PVSPSAVEED EDEDGHTVVA TARGIFNSNG GVLSSIETGV SIIIPQGAIP EGVEQEIYFK VCRDNSILPP LDKEKGETLL SPLVMCGPHG LKFLKPVELR LPHCDPKTWQ NKCLPGDPNY LVGANCVSVL IDHF (1446-1748 aa encoded by BC111712)
靶标信息
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686M05161; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); Tight junction protein ZO-1; zona occludens 1; Zona occludens protein 1; zonula occludens 1 protein; Zonula occludens protein 1
基因别名: TJP1; ZO-1; ZO1
UniProt ID: (Dog) O97758, (Human) Q07157
Entrez Gene ID: (Dog) 403752, (Human) 7082
