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Invitrogen
ZONAB Polyclonal Antibody
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产品信息
40-2800
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
C. elegans,
Dog,
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from an internal region of mouse ZONAB (ZO-1 associated nucleic acid-binding protein
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts with an internal region of the ZONAB protein. On Western blots, it identifies a major band at ~65 kDa and a minor band at ~54 kDa. The antibody is directed towards a region of ZONAB common to both the long and the alternatively-spliced short form. During development, reactivity was confirmed using mouse testis tissue homogenates by Western blotting and labeling of mouse testis tissue using immunofluorescence. All signals were absent in knockout mice, further confirming the reactivity with ZONAB.
靶标信息
Human DNA-binding protein (dbpA) is a member of a Y-box binding protein family containing a cold shock domain. The increased expression of Y box binding proteins in somatic cells is associated with cell proliferation and transformation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cold shock domain protein A; Cold shock domain-containing protein A; DNA-binding protein A; Muscle Y-box protein YB2; RYB-A; Y-box protein 3; Y-box-binding protein 3; Y-box-binding protein A; ZONAB A; ZONAB B
基因别名: Csda; Dbpa; Dpba; MSY3; MSY4; oxyR; Yb2; Ybx3
UniProt ID: (Rat) Q62764, (Mouse) Q9JKB3
Entrez Gene ID: (Rat) 83807, (Mouse) 56449
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
single-stranded DNA binding
mRNA 3'-UTR binding
poly(A) RNA binding
nucleic acid binding
RNA binding
protein binding
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
fertilization
organ regeneration
negative regulation of apoptotic process
positive regulation of organ growth
negative regulation of skeletal muscle tissue development
negative regulation of necroptotic process
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
