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Bethyl Laboratories
ZRANB3 Polyclonal Antibody
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ZRANB3 Antibody (A303-033A) in WB
Detection of human ZRANB3 by western blot and immunoprecipitation. Samples: Whole cell lysate from 293T (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HeLa (H; 50 µg) cells. Antibodies: Affinity purified rabbit anti-ZRANB3 antibody A303-033A used for WB at 0.1 µg/ml (A) and 1 µg/ml (B) and used for IP at 6 µg/mg lysate. ZRANB3 was also immunoprecipitated by rabbit anti-ZRANB3 antibody BL10989, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and... View More
产品信息
A303-033A
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Between 1029 and 1079
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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