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Invitrogen
ZSCAN4 Polyclonal Antibody
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产品信息
PA5-52303
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human ZSCAN4
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: CNDKASVKEK WKSSGKNLER FIEDLTDDSI NPPALVHVHM QGQEALFSED MPLRDVIVHL TKQVNAQTTR EANMGTPSQT SQDTSLETGQ GYEDEQDGWN SSSKTTRVNE NITNQGNQIV SLIIIQE
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 43%.
靶标信息
Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintenance and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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