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Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: homolog of Drosophila Zwilch; hZwilch; Protein zwilch homolog; zwilch kinetochore protein; Zwilch, kinetochore associated, homolog
基因别名: 2310031L18Rik; hZwilch; KNTC1AP; ZWILCH
UniProt ID: (Human) Q9H900, (Mouse) Q8R060
Entrez Gene ID: (Human) 55055, (Mouse) 68014, (Rat) 691493