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Invitrogen
Zansecimab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-59091
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4SP
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Zansecimab, also known as LY3127804, is a humanized IgG4 monoclonal antibody developed by Eli Lilly and Company, targeting angiopoietin 2 (Ang2). ANGPT2 (Angiopoietin-2) is a gene encoding a protein that plays a crucial role in angiogenesis, the process through which new blood vessels form from pre-existing vessels. Located on chromosome 8, ANGPT2 functions as a ligand for the TIE2 receptor, acting both as an agonist and antagonist depending on the physiological context. It disrupts the constitutive ANGPT1-TIE2 signaling, contributing to vascular destabilization and permeability, which is essential during inflammation and tumorigenesis. The regulation of ANGPT2 through alternative splicing and interactions with other angiogenic factors such as VEGF further modulates its role in pathological conditions, including cancer metastasis and inflammatory diseases. Inhibiting ANGPT2 has shown promise in preclinical studies as a strategy to reduce tumor growth and vascular complications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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