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Invitrogen
Zuberitamab Chimeric Recombinant Human Monoclonal Antibody
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产品信息
MA5-59189
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Zuberitamab, also known by its code name HS-006 and brand name Anruixi, is a biosimilar of rituximab that targets the CD20 antigen on B-cells. The CD20 gene, also known as MS4A1, encodes a B cell-specific membrane-bound protein that plays a crucial role in B cell development and function. Located on chromosome 11q12 in humans, the MS4A1 gene spans 16 kb and includes eight exons. CD20 is a part of the membrane-spanning 4-domain family, subfamily A (MS4A), which encompasses 18 tetraspan proteins. The prominent CD20 mRNA variant is 2.8 kb long, although other shorter variants exist. This phosphoprotein, approximately 33-37 kDa, is expressed on the surface of almost all normal and malignant B cells, making it an ideal target for therapeutic antibodies like rituximab. CD20 is known to interact with several proteins such as CD40, MHCII, and CD81, playing a role in B cell receptor signaling and other immune processes. Despite its widespread clinical use in B cell depletion therapies, the precise biological function of CD20 remains partly unresolved.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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