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Proteintech
Zyxin Monoclonal Antibody (4D7E7)
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产品信息
60254-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4D7E7
抗原
Zyxin Fusion Protein Ag0419 (278-572 aa encoded by BC008743)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: SKFSPGAPG GSGSQPNQKL GHPEALSAGT GSPQPPSFTY AQQREKPRVQ EKQHPVPPPA QNQNQVRSPG APGPLTLKEV EELEQLTQQL MQDMEHPQRQ NVAVNELCGR CHQPLARAQP AVRALGQLFH IACFTCHQCA QQLQGQQFYS LEGAPYCEGC YTDTLEKCNT CGEPITDRML RATGKAYHPH CFTCVVCARP LEGTSFIVDQ ANRPHCVPDY HKQYAPRCSV CSEPIMPEPG RDETVRVVAL DKNFHMKCYK CEDCGKPLSI EADDNGCFPL DGHVLCRKCH TARAQT (278-572 aa encoded by BC008743)
靶标信息
Zyxin is involved in focal adhesions, which are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Zyxin; Zyxin-2
基因别名: 9530098H06Rik; ESP-2; HED-2; R75157; ZYX
UniProt ID: (Human) Q15942, (Mouse) Q62523
Entrez Gene ID: (Human) 7791, (Mouse) 22793
