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Invitrogen
alpha-1 Antitrypsin Monoclonal Antibody (3B7)
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产品信息
HYB 191-01-02
产品规格
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3B7
抗原
a-1 AT isolated from human plasma.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.05 mg/mL
规格
210 µg
保存条件
4°C, store in dark
运输条件
Wet ice
RRID
产品详细信息
HYB 191-01-02 has specificity for human a-1 AT, native and denatured.
HYB 191-01-02 has been successfully used in Western blotting and ELISA procedures. HYB 191-01-02 reacts strongly with a-1 AT. Strong reaction is seen in ELISA with native and denatured a-1 AT directly coated onto the microtiter well. When tested in sandwich ELISA in combination with a polyclonal antibody against a-1 AT (e.g. DAKO A0012), it only recognizes native a-1 AT. In Western blotting after SDS-PAGE, HYB 191-01-02 reacts with native and denatured a-1 AT in reduced as well as non-reduced forms.
The HYB 191-01-02 immunogen is a-1 AT isolated from human plasma.
The HYB 191-01-02 epitope differs from that of HYB 185-02-02.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
靶标信息
Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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