Nordic

alpha-2 Macroglobulin Polyclonal Antibody

Name: alpha-2 Macroglobulin Polyclonal Antibody
Brand: Nordic
SKU: RAAM-A2M

查看其他43个A2M抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

RAAM-A2M

应用

建议稀释比

已发表文章

免疫电泳 (IE)

120 µL

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG

分类

Polyclonal

类型

Antibody

抗原

Moue alpha-2 macroglobulin

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

保存液

whole serum

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute the lyophilized antiserum by adding 1 mL sterile distilled water.

Inter-species cross reactivity is a normal feature of antibodies to Serum proteins, since homologous proteins of different species frequently share antigenic determinants. Cross-reactivity of this antiSerum has been tested in double radial immunodiffusion (Ouchterlony) with the following results: Bovine - Cat - Chicken - Dog - ferret - Goat - Guinea Pig - Hamster - Horse - Human - Monkey - Rabbit - Sheep - Swine - Turkey -.

In immunoelectrophoresis use 2 µL serum or equivalent against 120 µL antiserum. In double radial immunodiffusion use a rosette arrangement with 10 µL antiserum in 3 mm diameter centre well and 2 µL serum samples (neat and serially diluted) in 2 mm diameter peripheral wells.

Dilutions may be prepared by adding phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the antiserum. Diluted antiserum should be stored at 4°C, not refrozen, and preferably used the same day.

靶标信息

Alpha 2-Macroglobulin (a2M), is a approximately 720-kDa homotetrameric glycoprotein composed of four identical approximately 180 kDa subunits. aAlpha 2M shares with other alpha-macroglobulins, like the complement components C3 and C4 and the pregnancy zone protein PZP, an extraordinary binding capacity for a variety of ligands. This allows the alpha-macroglobulins to serve as humoral defense barriers against foreign peptides in the plasma. Alpha 2M interacts and captures virtually any proteinase, often referred to as a panprotease inhibitor. In the brain of Alzheimer's disease (AD) patients, Alpha 2M also has been localized to diffuse amyloid plaques, supporting an important role for alpha 2M in AD etiopathology.

仅用于科研。不用于诊断过程。未经明确授权不得转售。