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Invitrogen
alpha-II Spectrin Recombinant Rabbit Monoclonal Antibody (19H12L58)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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alpha-II Spectrin Antibody (703784) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of HeLa (Lane 1) and HeLa treated with Staurosporine (0.5mM for 5 hrs) (Lane 2). The blot was probed with Anti-alpha-II Spectrin Recombinant Rabbit Monoclonal Antibody (Product # 703784, 1:500 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 1:10000 dilution). A ~285 kDa band corresponding to alpha-II Spectrin was observed in the cell line tested along with its cleav... View More
产品信息
703784
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
19H12L58
抗原
Protein corresponding to human SPTAN1 [aa2330-aa2472]
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809248
产品详细信息
This antibody is predicted to react with Monkey, Bovine, Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
SPTAN1 (spectrin alpha chain, non-erythrocytic 1) is a part of the spectrin family of filamentous cytoskeletal proteins. They function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: (ALPHA)II-SPECTRIN; alpha; alpha-fodrin; Alpha-II spectrin; brain; FLJ44613; Fodrin alpha chain; Non erythrocytic spectrin alpha; non-erythrocytic 1 (alpha-fodrin); non-erythroid alpha chain; Spectrin; Spectrin alpha; Spectrin alpha chain brain; Spectrin alpha chain, non-erythrocytic 1; spectrin, non-erythroid alpha chain; Spectrin, non-erythroid alpha subunit
基因别名: EIEE5; NEAS; SPTA2; SPTAN1
UniProt ID: (Human) Q13813
Entrez Gene ID: (Human) 6709
