Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
图: 1 / 5
It is not recommended to aliquot this antibody.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alpha synuclein; Alpha-synuclein; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; synuclein alpha-140; synuclein, alpha (non A4 component of amyloid precursor)
基因别名: alphaSYN; NACP; PARK1; PARK4; PD1; SNCA; Syn
UniProt ID: (Human) P37840, (Rat) P37377, (Mouse) O55042
Entrez Gene ID: (Human) 6622, (Rat) 29219, (Mouse) 20617