Product References
Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease.
Frontiers in neurology
Moudio S,Rodin F,Albargothy NJ,Karlsson U,Reyes JF,Hallbeck M
701085 was used in Immunohistochemistry, Western Blot to describe a simple and reliable method for the preparation of organotypic hippocampal slice cultures to investigate how the addition of α-synuclein in levels that do not cause acute toxicity impact cell viability over long periods of time, enabling the study of the cumulative effects of α-synuclein in a complex environment.
Tue Mar 22 00:00:00 EDT 2022
Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease.
Frontiers in neurology
Moudio S,Rodin F,Albargothy NJ,Karlsson U,Reyes JF,Hallbeck M
701085 was used in Immunohistochemistry, Western Blot to describe a simple and reliable method for the preparation of organotypic hippocampal slice cultures to investigate how the addition of α-synuclein in levels that do not cause acute toxicity impact cell viability over long periods of time, enabling the study of the cumulative effects of α-synuclein in a complex environment.
Tue Mar 22 00:00:00 EDT 2022
Development of a physiologically relevant and easily scalable LUHMES cell-based model of G2019S LRRK2-driven Parkinson's disease.
Disease models & mechanisms
Calamini B,Geyer N,Huss-Braun N,Bernhardt A,Harsany V,Rival P,Cindhuchao M,Hoffmann D,Gratzer S
Published figure using alpha Synuclein recombinant monoclonal antibody (Product # 701085) in Western Blot
Tue Jun 01 00:00:00 EDT 2021
Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia.
Frontiers in molecular neuroscience
Sackmann V,Sinha MS,Sackmann C,Civitelli L,Bergström J,Ansell-Schultz A,Hallbeck M
701085 was used in Western Blotting to show that altering sphinolipids can mitigate the spread of α-syn, even under hypoxic conditions, potentially suppressing Parkinson's disease progression.
Wed Sep 30 00:00:00 EDT 2020
DNA damage as a marker of brain damage in individuals with history of concussions.
Laboratory investigation; a journal of technical methods and pathology
Schwab N,Tator C,Hazrati LN
701085 was used in Immunohistochemistry to investigate the DNA damage caused by mild traumatic brain injuries in two men with a history of concussions. Immunohistochemistry revealed extensive DNA damage throughout the frontal cortex, hippocampus, and brainstem areas.
Mon Jul 01 00:00:00 EDT 2019
DNA repair deficiency and senescence in concussed professional athletes involved in contact sports.
Acta neuropathologica communications
Schwab N,Grenier K,Hazrati LN
701085 was used in Immunohistochemistry to assess clinical presentation, neuropathological changes, load of DNA damage, morphological markers of cellular senescence, and expression of genes involved in DNA damage signaling, DNA repair, and cellular senescence including the senescence-associated secretory phenotype (SASP) in 38 professional athletes.
Thu Nov 14 00:00:00 EST 2019
Altered Gut Microbiome in Parkinson's Disease and the Influence of Lipopolysaccharide in a Human α-Synuclein Over-Expressing Mouse Model.
Frontiers in neuroscience
Gorecki AM,Preskey L,Bakeberg MC,Kenna JE,Gildenhuys C,MacDougall G,Dunlop SA,Mastaglia FL,Akkari PA,Koengten F,Anderton RS
701085 was used in Western Blotting to show lipopolysaccharides administration in mice causes earlier motor troubles and also an altered gut microbiome is present in patients with Parkinson's disease.
Tue Sep 29 00:00:00 EDT 2020
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.
Scientific reports
Höllerhage M,Moebius C,Melms J,Chiu WH,Goebel JN,Chakroun T,Koeglsperger T,Oertel WH,Rösler TW,Bickle M,Höglinger GU
Published figure using alpha Synuclein monoclonal antibody (Product # 701085) in Western Blot
Wed Sep 13 00:00:00 EDT 2017
Protective efficacy of phosphodiesterase-1 inhibition against alpha-synuclein toxicity revealed by compound screening in LUHMES cells.
Scientific reports
Höllerhage M,Moebius C,Melms J,Chiu WH,Goebel JN,Chakroun T,Koeglsperger T,Oertel WH,Rösler TW,Bickle M,Höglinger GU
Published figure using alpha Synuclein monoclonal antibody (Product # 701085) in Western Blot
Wed Sep 13 00:00:00 EDT 2017
Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.
Biochemistry
Lai Y,Kim S,Varkey J,Lou X,Song JK,Diao J,Langen R,Shin YK
701085 was used in western blot to examine the impact of nonaggregated α-Syn on SNARE-dependent liposome fusion.
Tue Jun 24 00:00:00 EDT 2014
α-Synuclein as an intrinsically disordered monomer--fact or artefact?
The FEBS journal
Coelho-Cerqueira E,Carmo-Gonçalves P,Pinheiro AS,Cortines J,Follmer C
701085 was used in western blot to study whether alpha-synuclein exists as an intrinsically disordered monomer
Tue Oct 01 00:00:00 EDT 2013