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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
流式细胞分析 (Flow) |
0.5 µg/1x10^6 cells | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rat / IgG2b |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
YTH470.5 |
抗原 |
Rat monoclonal antibody raised against human lymphocytes. |
偶联物 |
APC
|
激发/发射光谱 |
查看光谱
|
形式 |
Liquid |
浓度 |
0.1 mg/mL |
纯化类型 |
Protein G |
保存液 |
PBS with 4-5mg/mL BSA |
内含物 |
0.02% sodium azide |
保存条件 |
4° C, do not freeze |
RRID |
AB_2539073 |
MA5-17683 targets Beta 2-microglobulin in FACS and WB applications and shows reactivity with Human samples.
The MA5-17683 immunogen is rat monoclonal antibody raised against human lymphocytes.
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
蛋白别名: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m
基因别名: B2M; CDABP0092; HDCMA22P; IMD43
UniProt ID: (Human) P61769
Entrez Gene ID: (Human) 567
