GenScript

beta-Amyloid 1-42 Monoclonal Antibody (2C2G5)

查看其他6个Amyloid beta 42抗体

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beta-Amyloid 1-42 Monoclonal Antibody (2C2G5)

产品信息

A01567-40

应用
建议稀释比
已发表文章

免疫组化（石蜡） (IHC (P))

1.0-5.0 µg/mL
-

酶联免疫吸附实验 (ELISA)

0.05-0.2 µg/mL
-

点杂交 (DB)

0.1-1.0 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG

分类

Monoclonal

类型

Antibody

克隆号

2C2G5

抗原

KLH conjugated synthetic peptide derived from human beta-Amyloid 1-42
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute 40 µg lyophilized powder with 80 µL of deionized water (or equivalent) to antibody concentration of 0.5 mg/mL.

A number of mutations, identified in the gene encoding the β-amyloid precursor protein (βAPP), have been linked to early-onset Familial Alzheimers Disease. βAPP is cleaved sequentially by the proteolytic enzymes β-secretase and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42(43) and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides can bind to scavenger receptors and the receptor for advanced glycation end products. Aβ peptides are degraded either via a reuptake mechanism followed by endosomal degradation or by an extracellular insulin-degrading enzyme. Extracellular accumulation of Aβ leads to formation of aggregates, fibrils, and eventually amyloid deposits called neuritic plaques, a hallmark of Alzheimer's disease. β-amyloid antibodies and peptides have been developed as tools for elucidating the biology of Alzheimers disease.GenScript Human β-Amyloid 1-42 Antibody (2C2G5), mAb, Mouse is produced from the hybridoma resulting from fusion of Sp2/0 myeloma and B-lymphocytes obtained from mouse immunized with a synthetic peptide corresponding to amino acids 36-42 of human β-Amyloid conjugated to KLH (Swiss Prot: P05067).

Upon reconstitution, it can be stored for 2-3 weeks at 2-8 °C or for up to 12 months at -20 °C or below.

靶标信息

Beta amyloid is a 40-43 amino acid peptide cleaved from amyloid precursor protein by a protease, gamma-secretase. Beta Amyloid (1-40) (Amyloid beta 40 or Abeta 40) together with beta Amyloid (1-42) (Amyloid beta 42 or Abeta 42) are two major C-terminal variants of the amyloid beta protein, constituting the majority of amyloid beta proteins. Both the Amyloid beta 40 and Amyloid beta 42 alloforms are major components of the extracellular plaques found in Alzheimer's disease brain tissue.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: A beta 1 42; A β 1 42; AB42; ABPP; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; Amyloid; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; Amyloid beta 1 42; Amyloid precursor protein; Amyloid β; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; APP; APPI; Aβ 1 42; B APP42; BAPP42; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; BetaAPP42; Cerebral vascular amyloid peptide; CVAP; peptidase nexin-II; PN-II; PreA4; Protease nexin-II; testicular tissue protein Li 2; β APP42; βAPP42

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基因别名: A4; AAA; ABETA; ABPP; AD1; APP; APPI; CTFgamma; CVAP; PN-II; PN2

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UniProt ID: (Human) P05067

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Entrez Gene ID: (Human) 351

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功能
DNA binding serine-type endopeptidase inhibitor activity receptor binding protein binding heparin binding peptidase activator activity enzyme binding identical protein binding transition metal ion binding PTB domain binding growth factor receptor binding protease inhibitor
参与通路
response to yeast suckling behavior platelet degranulation mRNA polyadenylation regulation of translation protein phosphorylation cellular copper ion homeostasis endocytosis response to oxidative stress cell adhesion regulation of epidermal growth factor-activated receptor activity Notch signaling pathway axonogenesis mating behavior locomotory behavior axo-dendritic transport cholesterol metabolic process adult locomotory behavior visual learning cellular process response to lead ion negative regulation of endopeptidase activity positive regulation of peptidase activity positive regulation of G2/M transition of mitotic cell cycle axon midline choice point recognition neuron remodeling dendrite development antibacterial humoral response antifungal humoral response extracellular matrix organization forebrain development neuron projection development ionotropic glutamate receptor signaling pathway regulation of multicellular organism growth regulation of protein binding cellular protein metabolic process innate immune response negative regulation of neuron differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter collateral sprouting in absence of injury regulation of synapse structure or activity defense response to Gram-negative bacterium defense response to Gram-positive bacterium neuromuscular process controlling balance synaptic growth at neuromuscular junction neuron apoptotic process smooth endoplasmic reticulum calcium ion homeostasis cellular response to cAMP cellular response to norepinephrine stimulus amyloid fibril formation cellular response to nerve growth factor stimulus
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